On the case study page you will see how different collections of symptoms afflict each person.
If you only suffer from a handful of the symptoms below, particularly neurological, it is advisable to get yourself tested and educate yourself about this deficiency.
Please note hypo-thyroidism, hyper-thyroidism, coeliac disease and pyroluria manifest with similar symptoms, and are common co-existing conditions.
Neurological - Neurological symptoms must be treated with B12 injections every other day until the symptoms stop improving.
- Tinnitus
- Tremor
- Paresthesia - numbness, tingling and pain
- Confusion / disorientation
- Weakness of legs, arms, trunk
- Impaired vibration - position sense
- Abnormal reflexes
- Unsteady or abnormal gait / falls
- Ataxia (Neurological disorder affecting balance, coordination and speech)
- Balance problems
- Difficulty walking
- Dizziness
- Restless legs
- Visual disturbances / decreased-blurred vision / damage of optic nerve
- Forgetfulness, memory loss
- Dementia / intellectual deterioration
- Impotence
- Paralysis
- Impaired fine motor coordination
- Muscular spasticity
- Bladder or bowel incontinence
- Impaired pain perception
- Nocturnal cramping
- Disturbance in taste and smell
- Optic atrophy
Neuropsychiatric
- Confusion/disorientation
- Psychosis
- Post natal depression
- Hallucinations
- Memory loss
- Delusion
- Depression
- Suicidal ideation
- Mania
- Anxiety
- Paranoia
- Irritability
- Apathy
- Personality changes
- Inappropriate sexual behaviour
- Violent/aggressive behaviour
- Schizophrenic symptoms
- Sleep disturbances
- Insomnia
- Changes in taste, smell, vision, and sensory/motor function which can be mistaken for psychiatric problems
Haematological signs and symptoms
- Anaemia
- Macrocytosis (large red blood cells)
- Hyper segmented neutrophils
- Generalised weakness, fatigue
- Breathlessness
- Pallor / jaundice
- Chronic fatigue
Vascular Problems
- Orthostatic hypotension/ Postural hypotension (low blood pressure when standing, which can cause fainting and falls)
- Postural orthostatic tachycardia
- palpitations
- Occlusive vascular disorder
- Transient ischemic attacks (TIAs, or 'mini stroke')
- Cerebral vascular accident (CVA or 'stroke')
- Myocardial infarction ('heart attack')
- DVT - Deep vein thrombosis (blood clot to the leg or arm)
- PE - Pulmonary embolism
Female
- Infertility
- Recurrent miscarriage
- Abnormal PAP smears
- Intrauterine growth retardation
Male
- Infertility
- Impotence
- Low sperm motility
- Low sperm count
Gastrointestinal - signs and risk factors
- Loss of appetite/weight loss or anorexia
- Epigastric pain (poor digestion, bloated feeling after eating small or normal sized meals)
- IBS - Irritable bowel syndrome
- Constipation
- GERD - Gastric reflux disease - ulcers / mouth ulcers
- Giardiasis
- Pancreatitis, pancreatic exocrine insufficiency
- Decreased stomach acid
- Gastropareisis
- Helicobactor pylori infection
- SIBO Small intestinal bacterial overgrowth
- Gastrectomy (partial or complete) - bariatric surgery
- Illeal resection (partial or complete)
- Malabsorption syndromes - Crohn's disease, coeliac disease etc)
- Liver disease
- Diphyllobothrium latum (fish tapeworm)
Additional Signs and Symptoms
- Dry cracked corners of the mouth
- Premature greying
- Glossitis - swollen / sore tongue, geographic tongue
- Fainting/light headedness
- Osteoporosis
- Fractures
- Suppressed activity of osteoblasts (cells that build bone)
- Symptoms mimicking Parkinson's and MS
- Nominal aphasia - difficulty recalling names or words
- Radiculopathy - chronic pain disorder
- Increased susceptibility to infections
- Poor wound healing
- Malnutrition
- Enlarged spleen (splenomegaly)
- Enlarged liver (hepatomegaly)
- Skin hyper pigmentation or hypo pigmentation
- Poor antibody production following vaccines
- MTHFR Gene mutation
List Information provided with kind permission of Sally M. Pacholok R.N. & Dr. Jeffrey J. Stuart.
